BAZ2-ICR, BAZ2 Bromodomain Inhibitor


Catalog No. size PriceQuantity
M60226-2S 2 mg solid $129
M60226-10S 10mg solid $522

Description

Product Information
Molecular Weight: 357.41
Formula: C20H19N7
Purity: 98%
CAS#: 1665195-94-7
Solubility: DMSO up to 100 mM
Chemical Name: 4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

BAZ2-ICR is a potent and selective BAZ2 bromodomain inhibitor with Kd values of 109 and 170 nM for BAZ2A and BAZ2B, respectively. It exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. It shows accelerated FRAP recovery at 1 ¦ÌM in the BAZ2A FRAP assay.

How to Use:

In vitro: BAZ2-ICR was used at 1-10  final concentration in various in vitro assays.

In vivo: n/a

Reference:

1. http://www.thesgc.org/chemical-probe/BAZ2-ICR

Products are for research use only. Not for human use.

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