|Solubility:||DMSO up to 100 mM|
|Chemical Name:||sodium (E)-5-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-2,4-dimethylbenzenesulfonate|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
Ischemin is a potent, selective and cell permeable CBP bromodomain inhibitor. It inhibits the acetyl-lysine binding activity of the bromodomain of CBP. It alters post-translational modifications on p53 and histones, inhibits p53 interaction with CBP and transcriptional activity in cells, and prevents Doxorubicin-induced apoptosis in ischemic cardiomyocytes. Ischemin is a good chemical probe to modulate acetylation-mediated interactions in gene transcription and a new approach to therapeutic interventions of human disorders such as myocardial ischemia
How to Use:
In vitro: Ischemin was used at 10-50 µM final concentration in various in vitro assays.
In vivo: n/a
- 1. Borah JC, et al. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. (2011) Chem Biol. 18(4):531-41.
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