MS436, BRD4 Inhibitor


Catalog No. size PriceQuantity
M60232-2S 2 mg solid $109
M60232-10S 10mg solid $431

Description

Product Information
Molecular Weight: 383.42
Formula: C18H17N5O3
Purity: ≥98%
CAS#: 1395084-25-9
Solubility: DMSO up to 100 mM
Chemical Name: (E)-4-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-N-(pyridin-2-yl)benzenesulfonamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

MS436 is a potent and selective BET bromodomain inhibitor with Ki of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively. It effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages without siginificanty inhibition on cell viability. MS436 represents a new class of bromodomain inhibitors to study the functional differences of the two bromodomains of BRD4

How to Use:

In vitro: MS436 was used at 10-100 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. Zhang G, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. (2013) J Med Chem. 56(22):9251-64. 
    
  

Products are for research use only. Not for human use.

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