Description
Product Information
| Molecular Weight: | 383.42 |
| Formula: | C18H17N5O3 |
| Purity: | ≥98% |
| CAS#: | 1395084-25-9 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | (E)-4-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-N-(pyridin-2-yl)benzenesulfonamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
MS436 is a potent and selective BET bromodomain inhibitor with Ki of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively. It effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages without siginificanty inhibition on cell viability. MS436 represents a new class of bromodomain inhibitors to study the functional differences of the two bromodomains of BRD4
How to Use:
In vitro: MS436 was used at 10-100 µM final concentration in various in vitro assays.
In vivo: n/a
Reference:
- 1. Zhang G, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. (2013) J Med Chem. 56(22):9251-64.
Products are for research use only. Not for human use.
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