CAY10603, HDAC6 Inhibitor


Catalog No. size PriceQuantity
M60234-2S 2 mg solid $129
M60234-10S 10 mg solid $510

Description

Product Information
Molecular Weight: 446.50
Formula: C22H30N4O6
Purity: ≥98%
CAS#: 1045792-66-2
Solubility: DMSO up to 100 mM
Chemical Name: tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM. It has 271 nM, 252 nM, 0.42 nM, 6851 nM, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. CAY10603 has potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 μM. It could be useful chemical probe to study HDAC biology.

How to Use:

In vitro: CAY10603 was used at 0.1-1 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • Kozikowski AP, et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. (2008) J Med Chem. 51(15):4370-3. 

Products are for research use only. Not for human use.

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