L755,507, CRISPR Editing Enhancer


Catalog No. size PriceQuantity
M60237-2S 2 mg solid $89
M60237-10S 10 mg solid $360

Description

Product Information

MolecularWeight:

584.73

Formula:

C30H40N4O6S

Purity:

≥98%

CAS#:

159182-43-1

Solubility:

DMSO up to 100 mM

Chemical Name:

(S)-4-(3-hexylureido)-N-(4-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide

Storage:

Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

L-755,507 was previously characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 ~0.43 nM.  It has > 1000 fold selectivity overβ1- and β2-adrenoceptors (EC50 ~ 580 nM and >10000 nM forβ1- and β2-adrenoceptors respectively). It stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). In a recent study, L-755,507 was identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. 

How to Use:

In vitro:  L-755,507 was used at 1-5 µM final concentration in various in vitro assays.

In vivo: L-755,507 stimulates metabolic rate by 30% after acute bolus intravenous administration of 0.1 mg/kg to rhesus monkeys.

Reference:

  • 1.     Fisher MH, et al. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. (1998) J Clin Invest.101(11):2387-93.
  • 2.     Parmee ER, et al. Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist. (1998) Bioorg Med Chem Lett. 8(9):1107-12.
  • 3.     Yu C, et al. Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells. (2015) Cell Stem Cell 16(2):142-7.

 


Products are for research use only. Not for human use.

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