L755,507, CRISPR Editing Enhancer


Catalog No. size PriceQuantity
M60237-2S 2 mg solid $89
M60237-10S 10 mg solid $360

Description

L-755, 507 was previously characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 ~0.43 nM. It has > 1000 fold selectivity overβ1- and β2-adrenoceptors (EC50 ~ 580 nM and >10000 nM forβ1- and β2-adrenoceptors respectively). It stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). In a recent study, L-755, 507 was identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.

Product information

CAS Number: 159182-43-1

Molecular Weight: 584.73

Formula: C30H40N4O6S

Chemical Name: (S)-4-(3-hexylureido)-N-(4-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide

Smiles: CCCCCCNC(=O)NC1C=CC(=CC=1)S(=O)(=O)NC1C=CC(CCNC[C@H](O)COC2=CC=C(O)C=C2)=CC=1

InChiKey: NYYJKMXNVNFOFQ-MHZLTWQESA-N

InChi: InChI=1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

L-755, 507 was used at 1-5 µM final concentration in various in vitro assays.

In Vivo:

L-755, 507 stimulates metabolic rate by 30% after acute bolus intravenous administration of 0.1 mg/kg to rhesus monkeys.

References:

  1. Fisher MH, et al. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. (1998) J Clin Invest.101(11):2387-93.
  2. Parmee ER, et al. Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist. (1998) Bioorg Med Chem Lett. 8(9):1107-12.
  3. Yu C, et al. Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells. (2015) Cell Stem Cell 16(2):142-7.

Products are for research use only. Not for human use.


Documents

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed