SR10067 --- REV-ERB Agonist

Catalog No. size PriceQuantity
M60240-2S 2 mg solid $129
M60240-10S 10mg solid $535


SR-10067 is a selective Rev-Erbα/β agonist that increases wakefulness, reduces REM and slow wave sleep in vivo. It also reduces anxiety-like behavior, is cell permeable, and is brain penetrant.

Product information

CAS Number: 1380548-02-6

Molecular Weight: 465.58

Formula: C31H31NO3

Chemical Name: (3-((4-(tert-butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone

Smiles: CC(C)(C)OC1C=CC(=CC=1)OCC1CC2=CC=CC=C2CN1C(=O)C1=CC=CC2=CC=CC=C21


InChi: InChI=1S/C31H31NO3/c1-31(2,3)35-27-17-15-26(16-18-27)34-21-25-19-23-10-4-5-11-24(23)20-32(25)30(33)29-14-8-12-22-9-6-7-13-28(22)29/h4-18,25H,19-21H2,1-3H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

SR10067 was used at 5-10 µM concentration in vitro and in cellular assays.

In Vivo:

IP administration of SR10067 was used at 30 mg/kg to mice.


  1. Banerjee S, et al. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. (2014) Nat Commun. 5:5759.

Products are for research use only. Not for human use.


Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed