SR10067, REV-ERB Agonist

SR-10067 is a selective Rev-Erbα/β agonist that increases wakefulness, reduces REM and slow wave sleep in vivo. It also reduces anxiety-like behavior, is cell permeable, and is brain penetrant.

Product information

CAS Number: 1380548-02-6

Molecular Weight: 465.58

Formula: C31H31NO3

Chemical Name: (3-((4-(tert-butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone

Smiles: CC(C)(C)OC1C=CC(=CC=1)OCC1CC2=CC=CC=C2CN1C(=O)C1=CC=CC2=CC=CC=C21

InChiKey: MOPAGKWBFUICQT-UHFFFAOYSA-N

InChi: InChI=1S/C31H31NO3/c1-31(2,3)35-27-17-15-26(16-18-27)34-21-25-19-23-10-4-5-11-24(23)20-32(25)30(33)29-14-8-12-22-9-6-7-13-28(22)29/h4-18,25H,19-21H2,1-3H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

SR10067 was used at 5-10 µM concentration in vitro and in cellular assays.

In Vivo:

IP administration of SR10067 was used at 30 mg/kg to mice.

References:

1. Banerjee S, et al. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. (2014) Nat Commun. 5:5759.

Products are for research use only. Not for human use.