|Solubility:||DMSO up to 100 mM|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
SGC707 is a potent, selective and cell permeable allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 31 nM. It has >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well-characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease.
How to Use:
In vitro: SGC707 was used at 5-10 µM final concentration in various in vitro assays.
In vivo: n/a
- 1. Kaniskan HÜ, et al. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). (2015) Angew Chem Int Ed Engl. In press.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.