TAME, Ubiquitin Ligase APC/C Inhibitor


Catalog No. size PriceQuantity
M60246-2S 2 mg solid $79
M60246-10S 10 mg solid $312

Description

Product Information
Molecular Weight: 378.87
Formula: C14H22N4O4S.HCl
Purity: ≥98%
CAS#: 1784-03-8
Solubility: DMSO and water up to 100 mM
Chemical Name: (S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate, hydrochloride
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

TAME is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). It promotes Cdc20 autoubiquitination and inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 ~ 12 μM) and blocks cyclin degradation in interphase extract.

How to Use:


In vitro: 
TAME was used at 50-200 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. (2010) Cancer Cell. 18(4):382-95. 
  • 2. Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. (2012) Nat Chem Biol. 8(4):383-92. 


Products are for research use only. Not for human use. 

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed