TAME, Ubiquitin Ligase APC/C Inhibitor

Catalog No. size PriceQuantity
M60246-2S 2 mg solid $79
M60246-10S 10 mg solid $312


Product Information
Molecular Weight: 378.87
Formula: C14H22N4O4S.HCl
Purity: ≥98%
CAS#: 1784-03-8
Solubility: DMSO and water up to 100 mM
Chemical Name: (S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate, hydrochloride
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

TAME is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). It promotes Cdc20 autoubiquitination and inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 ~ 12 μM) and blocks cyclin degradation in interphase extract.

How to Use:

In vitro: 
TAME was used at 50-200 µM final concentration in various in vitro assays.
In vivo: n/a


  • 1. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. (2010) Cancer Cell. 18(4):382-95. 
  • 2. Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. (2012) Nat Chem Biol. 8(4):383-92. 

Products are for research use only. Not for human use. 

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