A01, Smurf1 E3 Ubiquitin Ligase Inhibitor

Catalog No. size PriceQuantity
M60249-2S 2 mg solid $109
M60249-10S 10mg solid $436


Product Information
Molecular Weight: 512.93
Formula: C22H20ClF3N4O3S
Purity: ≥98%
CAS#: 1007647-73-5
Solubility: DMSO up to 100 mM
Chemical Name: (4-((4-chloro-3-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

A01 is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3.7 nM. It attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. It also potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.

How to Use:

In vitro:A01 was used at 1-10 µM final concentration in various in vitro assays.
In vivo:n/a


  • 1. Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. (2014) Sci Rep. 4:4965.

Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed