Description
Product Information
| Molecular Weight: | 512.93 |
| Formula: | C22H20ClF3N4O3S |
| Purity: | ≥98% |
| CAS#: | 1007647-73-5 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | (4-((4-chloro-3-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
A01 is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3.7 nM. It attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. It also potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.
How to Use:
In vitro:A01 was used at 1-10 µM final concentration in various in vitro assays.
In vivo:n/a
Reference:
- 1. Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. (2014) Sci Rep. 4:4965.
Products are for research use only. Not for human use.
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