A01, Smurf1 E3 Ubiquitin Ligase Inhibitor


Catalog No. size PriceQuantity
M60249-2S 2 mg solid $109
M60249-10S 10mg solid $436

Description

Product Information
Molecular Weight: 512.93
Formula: C22H20ClF3N4O3S
Purity: ≥98%
CAS#: 1007647-73-5
Solubility: DMSO up to 100 mM
Chemical Name: (4-((4-chloro-3-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

A01 is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3.7 nM. It attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. It also potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.

How to Use:

In vitro:A01 was used at 1-10 µM final concentration in various in vitro assays.
In vivo:n/a

Reference:

  • 1. Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. (2014) Sci Rep. 4:4965.

Products are for research use only. Not for human use.

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