SMER3, SCF family E3 Ubiquitin Ligase Inhibitor


Catalog No. size PriceQuantity
M60250-2S 2 mg solid $129
M60250-10S 10mg solid $522

Description

SMER3 is a small molecule enhancer of rapamycin (SMER). It is also a specific inhibitor of Ubiquitin E3 ligase.

Product information

CAS Number: 67200-34-4

Molecular Weight: 224.18

Formula: C11H4N4O2

Chemical Name: 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one

Smiles: O=C1C2=NC3=NON=C3N=C2C2=CC=CC=C21

InChiKey: SFSSAKVWCKFRHE-UHFFFAOYSA-N

InChi: InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

SMER3 was used at 10-20 µM final concentration in various in vitro assays.

References:

  1. Aghajan M, et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. (2010) Nat Biotechnol. 28(7):738-42.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed