SMER3 is a small molecule enhancer of rapamycin (SMER). It is also a specific inhibitor of Ubiquitin E3 ligase.
CAS Number: 67200-34-4
Molecular Weight: 224.18
Chemical Name: 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 50 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
SMER3 was used at 10-20 µM final concentration in various in vitro assays.
- Aghajan M, et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. (2010) Nat Biotechnol. 28(7):738-42.
Products are for research use only. Not for human use.
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