SMER3, SCF family E3 Ubiquitin Ligase Inhibitor


Catalog No. size PriceQuantity
M60250-2S 2 mg solid $129
M60250-10S 10mg solid $522

Description

Product Information
Molecular Weight: 224.18
Formula: C11H4N4O2
Purity: ≥98%
CAS#: 67200-34-4
Solubility: DMSO up to 50 mM
Chemical Name: 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

SMER3 is a potent and selective a yeast SCF family E3 ubiquitin ligase inhibitor, also a small-molecule enhancers of rapamycin. It inhibits SCF(Met30), but not the closely related SCF(Cdc4). SMER3 can diminish binding of the F-box subunit Met30 to the SCF core complex in cell, induces the expression of MET genes and blocks cell proliferation.

How to Use:

In vitro: 
SMER3 was used at 10-20 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. Aghajan M, et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. (2010) Nat Biotechnol. 28(7):738-42.


Products are for research use only. Not for human use.

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