UNC2327 is a potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 230 nM. It occupies a novel allosteric binding site and is noncompetitive with both the peptide substrate and cofactor.
CAS Number: 1426152-53-5
Molecular Weight: 319.38
Chemical Name: 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(2-oxo-2-(piperidin-1-yl)ethyl)urea
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
UNC2327 was used at 5-10 µM final concentration in various in vitro assays.
- Liu F, et al. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. (2013) J Med Chem. 56(5):2110-24.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.