|Solubility:||DMSO up to 100 mM|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
UNC2327 is a potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 230 nM. It occupies a novel allosteric binding site and is noncompetitive with both the peptide substrate and cofactor.
How to Use:
In vitro: UNC2327 was used at 5-10 µM final concentration in various in vitro assays.
In vivo: n/a
- 1. Liu F, et al. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. (2013) J Med Chem. 56(5):2110-24.
Products are for research use only. Not for human use.
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