UNC2327, Allosteric PRMT3 Inhibitor


Catalog No. size PriceQuantity
M60253-2S 2 mg solid $129
M60253-10S 10mg solid $510

Description

Product Information
Molecular Weight: 319.38
Formula: C14H17N5O2S
Purity: ≥98%
CAS#: 1426152-53-5
Solubility: DMSO up to 100 mM
Chemical Name: 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(2-oxo-2-(piperidin-1-yl)ethyl)urea
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

UNC2327 is a potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 230 nM. It occupies a novel allosteric binding site and is noncompetitive with both the peptide substrate and cofactor.

How to Use:


In vitro: UNC2327 was used at 5-10 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. Liu F, et al. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. (2013) J Med Chem. 56(5):2110-24.

    
  

Products are for research use only. Not for human use. 

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