|Solubility:||DMSO up to 50 mM|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
OICR9429 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist (Kd ~24-52 nM). It has >100-fold selectivity over other methyltransferases tested. It disrupts WDR5 interaction with peptide regions of MLL and Histone 3. OICR-9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 µM.
How to Use:
In vitro: OICR9429 was used at 5-10 µM final concentration in various in vitro assays.
In vivo: n/a
- 1. http://www.thesgc.org/chemical-probes/OICR-9429.
Products are for research use only. Not for human use.
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