Furamidine dihydrochloride --- PRMT1 Inhibitor


Catalog No. size PriceQuantity
M60256-2S 2mg solid $99
M60256-10S 10 mg solid $391

Description

Furamidine is a potent, selective and cell permeable Protein arginine methyltransferase-1 (PRMT1) inhibitor with IC50 of 9.4 µM. It has >10-fold selectivity PRMT5, PRMT6 and CARM1 (IC50 are 166, 283 and >400 μM respectively). It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furamidine effectively inhibits intracellular PRMT1 activity and blocks cell proliferation in leukemia cell lines with different genetic lesions.

Product information

CAS Number: 55368-40-6

Molecular Weight: 377.27

Formula: C18H18Cl2N4O

Chemical Name: 4,4'-(furan-2,5-diyl)dibenzimidamide dihydrochloride

Smiles: Cl.Cl.NC(=N)C1C=CC(=CC=1)C1=CC=C(O1)C1C=CC(=CC=1)C(N)=N

InChiKey: VXNYQUQHOUERTR-UHFFFAOYSA-N

InChi: InChI=1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO and water up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Furamidine was used at 10-30 µM final concentration in various in vitro assays.

References:

  1. Yan L, et al. Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. (2014) J Med Chem. 57(6):2611-22.

Products are for research use only. Not for human use.

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