LLY-507, Protein-lysine Methyltransferase SMYD2 Inhibitor


Catalog No. size PriceQuantity
M60259-2S 2 mg solid $129
M60259-10S 10mg solid $522

Description

Product Information
Molecular Weight: 574.76
Formula: C36H42N6O
Purity: ≥98%
CAS#: 1793053-37-8
Solubility: DMSO up to 50 mM
Chemical Name: 5-cyano-2'-(4-(2-(3-methyl-1H-indol-1-yl)ethyl)piperazin-1-yl)-N-(3-(pyrrolidin-1-yl)propyl)-[1,1'-biphenyl]-3-carboxamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

LLY-507 is a potent, selective and cell permeable protein lysine methyltransferase SMYD2 inhibitor with IC50 <15 nM. It binds in the substrate peptide-binding pocket. It has >100-fold selectivity over other methyltransferases and other non-epigenetic targets. LLY-507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM. It inhibited the proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.

How to Use:

In vitro: LLY-507 was used at 10 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. Nguyen H, et al. LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. (2015) J Biol Chem. 290(22):13641-53. 

  
 

Products are for research use only. Not for human use. 

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed