Cyclosporin A, MPTP Inhibitor and HSC Protector


Catalog No. size PriceQuantity
M60262-2S 2 mg solid $79
M60262-10S 10 mg solid $320

Description

Cyclosporin A is an inhibitor of the mitochondrial permeability transition pore (MPTP). It protects mouse bone marrow and human cord blood HSCs from EPHOSS during collection in air, resulting in increased recovery of transplantable HSCs. It was used as immunosuppressant and could inhibit phosphatase activity of calcineurin (IC50 ~5 nM).

Product information

CAS Number: 59865-13-3

Molecular Weight: 1202.61

Formula: C62H111N11O12

Chemical Name: Cyclosporin A, MPTP Inhibitor and HSC Protector

Smiles: C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C

InChiKey: PMATZTZNYRCHOR-CGLBZJNRSA-N

InChi: InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM, EtOH up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Cyclosporin A was used at 50 µg/ml in the collection of cord blood process.

References:

  1. Mantel CR, et al. Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock. (2015) Cell. 161(7):1553-65.
  2. Yan P, et al. Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells. (2009) Biochem Biophys Res Commun. 379(1):115-20.
  3. Fruman DA, et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. (1992) Proc Natl Acad Sci USA. 89(9):3686-90.

Products are for research use only. Not for human use.

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