FG-4592 (Roxadustat), HIF Prolyl-Hydroxylases Inhibitor


Catalog No. size PriceQuantity
M60263-2S 2 mg solid $79
M60263-10S 10mg solid $324

Description

FG-4592 (Roxadustat) is a potent, selective and bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylase. It is an analog of 2-oxoglutarate (2-OG) to inhibit HIF-PH and prevent HIF turnover. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo. Right now FG-4592 is in phase III clinical trials to treat anemia.

Product information

CAS Number: 808118-40-3

Molecular Weight: 352.34

Formula: C19H16N2O5

Synonym:

Roxadustat

Chemical Name: (4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycine

Smiles: CC1=NC(C(=O)NCC(O)=O)=C(O)C2=CC=C(C=C21)OC1C=CC=CC=1

InChiKey: YOZBGTLTNGAVFU-UHFFFAOYSA-N

InChi: InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

FG-4592 was usually used at 10 µM final concentration in vitro.

References:

  1. Hsieh MM, et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. (2007) Blood. 15;110(6):2140-7.

Products are for research use only. Not for human use.

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