TRIM24-C34, BRPF1B/TRIM24 Dual Inhibitor


Catalog No. size PriceQuantity
M60265-2S 2 mg solid $99
M60265-10S 10mg solid $401

Description

Product Information
Molecular Weight: 499.54
Formula: C24H25N3O7S
Purity: ≥98%
CAS#: 1242907-48-7
Solubility: DMSO up to 20 mM
Chemical Name: 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

TRIM24-C34 is a potent, selective and cell permeable BRPF1B and TRIM24 dual inhibitor. It binds to bromodomain BRPF1B with a Kd of 137 nM, and the transcriptional regulator TRIM24 (also an E3 ubiquitin ligase) with a Kd of 222 nM. It has very good selectivity against other 45 bromodomains. Cellular activity of TRIM24-C34 was demonstrated using FRAP assays as well as cell viability data. It showed no significant cytotoxicity in the cell lines tested.

How to Use:

In vitro: TRIM24-C34 was used at 10 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

  • 1. Bennett J, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. (2015) J Med Chem. In press. 


Products are for research use only. Not for human use. 

 

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