FASCIN-G2, Fascin Inhibitor


Catalog No. size PriceQuantity
M60269-2S 2 mg solid $129
M60269-10S 10 mg solid $516

Description

Product Information
Molecular Weight: 385.34
Formula: C20H14F3N3O2
Purity: ≥98%
CAS#: n/a
Solubility: DMSO up to 50 mM
Chemical Name: N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)furan-2-carboxamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

FASCIN-G2 is a potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin with Kd ~5-20 µM. It specifically blocks filopodial formation, tumour cell migration and invasion in vitro. , FASCIN-G2 showed very good in vivo efficacy in 4T1 mammary tumour metastasis model and in MDA-MB-231 human breast tumour metastasis model.

How to Use:


In vitro: FASCIN-G2 was usually used at 10-50 µM final concentration in vitro.
In vivo: FASCIN-G2 was dosed to mice by intraperitoneal injection at 100 mg/Kg once per day in 4T1 mammary tumour metastasis model or in MDA-MB-231 human breast tumour metastasis model.

Reference:

  • 1. Huang FK, et al. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. (2015) Nat Commun. 6:7465.

Products are for research use only. Not for human use. 

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