AMI-1 is a potent and selective arginine methyltransferase inhibitor, is also a potent scavenger of NADPH-oxidase-derived superoxide. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements.
CAS Number: 20324-87-2
Molecular Weight: 548.45
Chemical Name: sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate)
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM, Water up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
AMI-1 was used at 10-30 µM final concentration in vitro and in cellular assays.
AMI-1 was dosed by intranasal injection to Chronic AIPI rats at 50 μL (concentration of 0.1 mg/mL).
- Cheng D, et al. Small molecule regulators of protein arginine methyltransferases. (2004) J Biol Chem. 279(23):23892-9.
- Sun Q, et al. PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation. (2015) J Immunol. 195(1):298-306.
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