I-BRD9, Bromodomain Containing Protein 9 (BRD9) Inhibitor

Catalog No. size PriceQuantity
M60276-2S 2 mg solid $129
M60276-10S 10 mg solid $529


Product Information
Molecular Weight: 497.55
Formula: C22H22F3N3O3S2
Purity: ≥98%
CAS#: 1714146-59-4
Solubility: DMSO up to 100 mM
Chemical Name: N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-dihydrothieno[3,2-c]pyridine-2-carboximidamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

I-BRD9 is a potent, selective and cell permeable Bromodomain Containing Protein 9 (BRD9) inhibitor with Kd ~1.9 nM. It has >700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7). It downregulates CLEC1, DUSP6, FES and SAMSN1 genes in Kasumi-1 cells. I-BRD9 is the first selective tool compound available to elucidate the cellular phenotype of BRD9 bromodomain inhibition.

How to Use:

In vitro: I-BRD9 was used at 10 µM final concentration in vitro and in cellular assays.

In vivo: n/a


  • 1. Theodoulou NH, et al. Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. (2015) J Med Chem. In press.

Products are for research use only. Not for human use. 

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