UF010, HDAC Inhibitor


Catalog No. size PriceQuantity
M60278-2S 2 mg solid $89
M60278-10S 10mg solid $352

Description

Product Information
Molecular Weight: 271.15
Formula: C11H15BrN2O
Purity: ≥98%
CAS#: 537672-41-6
Solubility: DMSO up to 100 mM
Chemical Name: 4-bromo-N'-butylbenzohydrazide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

UF010 is a potent and selective class I HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has >6-fold selectivity over other HDACs, and is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer cell lines.

How to Use:


In vitro: UF010 was used at 5-10 µM final concentration in vitro and in cellular assays.
In vivo: n/a

Reference:

  • 1. Wang Y, et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. (2015) Chem Biol. 22(2):273-84.



Products are for research use only. Not for human use. 

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