GNF-7, Ras Signaling Inhibitor

Catalog No. size PriceQuantity
M60281-2S 2 mg solid $129
M60281-10S 10mg solid $536


GNF-7 is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF-7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples.

Product information

CAS Number: 839706-07-9

Molecular Weight: 547.53

Formula: C28H24F3N7O2

Chemical Name: N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide

Smiles: CN1C2=NC(NC3=CC=C(C)N=C3)=NC=C2CN(C1=O)C1=CC(=CC=C1C)NC(=O)C1C=C(C=CC=1)C(F)(F)F


InChi: InChI=1S/C28H24F3N7O2/c1-16-7-9-21(34-25(39)18-5-4-6-20(11-18)28(29,30)31)12-23(16)38-15-19-13-33-26(36-24(19)37(3)27(38)40)35-22-10-8-17(2)32-14-22/h4-14H,15H2,1-3H3,(H,34,39)(H,33,35,36)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

GNF-7 was used at 1 µM final concentration in vitro and in cellular assays.

In Vivo:

GNF-7 was orally dosed to MOLT-3 xenotransplantation model at 7.5-15 mg/Kg once a day.


  1. Nonami A., et al. Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. (2015) Blood. 125(20):3133-43.

Products are for research use only. Not for human use.


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