GNF-7 is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF-7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples.
CAS Number: 839706-07-9
Molecular Weight: 547.53
Chemical Name: N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 50 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
GNF-7 was used at 1 µM final concentration in vitro and in cellular assays.
GNF-7 was orally dosed to MOLT-3 xenotransplantation model at 7.5-15 mg/Kg once a day.
- Nonami A., et al. Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. (2015) Blood. 125(20):3133-43.
Products are for research use only. Not for human use.
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