ML239, Breast Cancer Stem Cell Inhibitor


Catalog No. size PriceQuantity
M60282-2S 2 mg solid $129
M60282-10S 10mg solid $510

Description

Product Information
Molecular Weight: 346.60
Formula: C13H10Cl3N3O2
Purity: ≥98%
CAS#: 1378872-36-6
Solubility: DMSO up to 100 mM
Chemical Name: (E)-N'-((1H-pyrrol-2-yl)methylene)-2-(2,4,6-trichlorophenoxy)acetohydrazide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

ML239 is a potent and selective breast cancer stem cell inhibitor with IC50 ~1.16 μM. It displayed greater than 23-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_GFP). It did not significantly inhibit tumorsphere formation in the breast cancer cell line SUM159, which is a mixture of CSCs and differentiated cells. ML239 is also cytotoxic towards MDA-MB-231 breast cancer cells.

How to Use:


In vitro: ML239 was used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a

Reference:

  • 1. Carmody LC, et al. Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. (2012) J Biomol Screen. 17(9):1204-10. 
  • 2. Germain AR, et al. Identification of a selective small molecule inhibitor of breast cancer stem cells. (2012) Bioorg Med Chem Lett. 22(10):3571-4.
  • 3. http://www.ncbi.nlm.nih.gov/books/NBK133423/


Products are for research use only. Not for human use. 

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