DMOG, Prolyl 4-hydroxylase (P4H) Inhibitor


Catalog No. size PriceQuantity
M60287-2S 2 mg solid $79
M60287-10S 10 mg solid $320

Description

Product Information
Molecular Weight: 175.14
Formula: C6H9NO5
Purity: ≥98%
CAS#: 89464-63-1
Solubility: DMSO up to 100 mM; Water up to 100 mM
Chemical Name: methyl 2-((2-methoxy-2-oxoethyl)amino)-2-oxoacetate
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

DMOG is a selective, competitive and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG acts as a pro-angiogenic compound, acting via the HIF-1α system.

How to Use:


In vitro: DMOG was used at 100 µM final concentration in vitro and in cellular assays.
In vivo: n/a


Reference:

  • 1. Jaakkola P, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. (2001) Science. 292(5516):468-72. 
  • 2. Lomb DJ, et al. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons. (2009) Mol Pharmacol. 75(5):1198-209. 
  • 3. Ayrapetov MK, et al. Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. (2011) PLoS One. 6(10):e26064. 
  • 4. Barnucz E, et al. Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. (2013) J Pharmacol Exp Ther. 345(1):25-31.

 

Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed