|Solubility:||DMSO up to 100 mM; Water up to 100 mM|
|Chemical Name:||methyl 2-((2-methoxy-2-oxoethyl)amino)-2-oxoacetate|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
DMOG is a selective, competitive and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG acts as a pro-angiogenic compound, acting via the HIF-1α system.
How to Use:
In vitro: DMOG was used at 100 µM final concentration in vitro and in cellular assays.
In vivo: n/a
- 1. Jaakkola P, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. (2001) Science. 292(5516):468-72.
- 2. Lomb DJ, et al. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons. (2009) Mol Pharmacol. 75(5):1198-209.
- 3. Ayrapetov MK, et al. Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. (2011) PLoS One. 6(10):e26064.
- 4. Barnucz E, et al. Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. (2013) J Pharmacol Exp Ther. 345(1):25-31.
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