1,4-DPCA, Prolyl 4-hydroxylase (P4H) Inhibitor


Catalog No. size PriceQuantity
M60288-2S 2 mg solid $79
M60288-10S 10mg solid $312

Description

Product Information
Molecular Weight: 240.21
Formula: C13H8N2O3
Purity: ≥98%
CAS#: 331830-20-7
Solubility: DMSO up to 10 mM, EtOH up to 20 mM
Chemical Name: 4-oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

1,4-DPCA is a selective and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits α-prolyl4-hydroxylase, an oxygen-sensing enzyme that targets the pro-angiogenic factor  HIF-1α  for destruction upon hydroxylation of a specific proline residue. It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis.

How to Use:

In vitro:1,4-DPCA was used at 10 µM final concentration in vitro and in cellular assays.
In vivo:n/a

Reference:

  • 1. Jaakkola P, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. (2001) Science. 292(5516):468-72.
  • 2. Franklin TJ, et al. Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones. (2001) Biochem J. 353(Pt 2):333-8.
  • 3. Banerji B, et al. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. (2005) Chem Commun (Camb). (43):5438-40.

Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed