SirReal2, Sirt2 Inhibitor


Catalog No. size PriceQuantity
M60289-2D 2 mg in DMSO $119
M60289-2S 2 mg solid $119
M60289-10S 10mg solid $476

Description

Product Information
Molecular Weight: 420.55
Formula: C22H20N4OS2
Purity: ≥98%
CAS#: 709002-46-0
Solubility: DMSO up to 100 mM
Chemical Name: 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

SirReal2 is a potent and selective Sirt2 inhibitor with IC50  ~140 nM, has minimal effect on Sirt1 and Sirt3-6. It occupies the extended C-site and induces a major rearrangement of Sirt2’s active site, so it selectively inhibits Sirt2 and functions as a molecular wedge to lock Sirt2 in an open conformation. SirReal2 can increase tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. It could be a useful chemical tool for sirtuin biology.


How to use: 

In vitro: SirReal2 was used at 10-20 μ M final concentration in vitro and in cellular assays.
In vivo: n/a 

Reference:
  • 1. Rumpf T, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. (2015) Nat Commun. 6:6263. 


Products are for research use only. Not for human use. 

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed