NSC636819, KDM4A/KDM4B Inhibitor


Catalog No. size PriceQuantity
M60290-2S 2 mg solid $109
M60290-10S 10 mg solid $431

Description

Product Information
Molecular Weight: 510.15
Formula: C22H12Cl4N2O4
Purity: ≥98%
CAS#: 1618672-71-1
Solubility: DMSO up to 10 mM
Chemical Name: 4,4'-((1E,1'E)-(4,6-dinitro-1,3-phenylene)bis(ethene-2,1-diyl))bis(1,2-dichlorobenzene)
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.
Biological Activity:



NSC636819 is a cell permeable and selective novel active-site KDM4A/KDM4B inhibitor with IC50 ~6.4 μM for KDM4A and 9.3 μM for KDM4B. It inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. It also negatively regulates androgen-responsive genes. The overexpression of KDM4A/KDM4B in prostate cancer and their association with androgen receptor suggest that KDM4A/KDM4B are potential progression factors for prostate cancer.

How to Use:


In vitro:
 NSC636819 was used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a

Reference:

  • 1. Chu CH, et al. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. (2014) J Med Chem. 57(14):5975-85. 


Products are for research use only. Not for human use. 

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