|Solubility:||Water up to 5 mM (warming)|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
1-methyl-D-tryptophan (D-1MT) is a potent and selective indoleamine 2,3-dioxygenase (IDO) inhibitor with IC50 ~7 μM. It disrupts tryptophan catabolism and enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. It can reduce tumor volume in mice with xenografts overexpressing IDO.
In vitro: D-1MT was used at 10-50 µM final concentration in various in vitro assays.
In vivo: D-1MT was dosed at 5 mg/Kg orally to mice bearing A20 B-cell lymphoma.
- 1. Rytelewski M, et al. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. (2014) PLoS One. 9(2):e90439.
- 2. Nakamura N, et al. Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. (2015) Int J Hematol. 102(3):327-34.
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