1-methyl-D-tryptophan (D-1MT), IDO Inhibitor


Catalog No. size PriceQuantity
M60291-2S 2 mg solid $79
M60291-10S 10mg solid $320

Description

Product Information
Molecular Weight: 218.25
Formula: C12H14N2O2
Purity: ≥98%
CAS#: 110117-83-4
Solubility: Water up to 5 mM (warming)
Chemical Name: 1-methyl-D-tryptophan
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

1-methyl-D-tryptophan (D-1MT) is a potent and selective indoleamine 2,3-dioxygenase (IDO) inhibitor with IC50 ~7 μM.  It disrupts tryptophan catabolism and enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. It can reduce tumor volume in mice with xenografts overexpressing IDO.


How to Use:

In vitro: D-1MT was used at 10-50 µM final concentration in various in vitro assays.
In vivo: D-1MT was dosed at 5 mg/Kg orally to mice bearing A20 B-cell lymphoma.


Reference:

  • 1. Rytelewski M, et al. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. (2014) PLoS One. 9(2):e90439. 
  • 2. Nakamura N, et al. Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. (2015) Int J Hematol. 102(3):327-34.


Products are for research use only. Not for human use.

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