1-methyl-D-tryptophan (D-1MT) is a potent and selective indoleamine 2, 3-dioxygenase (IDO) inhibitor with IC50 ~7 μM. It disrupts tryptophan catabolism and enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. It can reduce tumor volume in mice with xenografts overexpressing IDO.
CAS Number: 110117-83-4
Molecular Weight: 218.25
Related CAS Number:
Chemical Name: 1-methyl-D-tryptophan
Appearance: White to off-white solid powder
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 5 mg/mL (22.91 mM; ultrasonic and adjust pH to 2 with HCl), 5 mM (warming); DMSO : 0.55 mg/mL (2.52 mM; Need ultrasonic and warming).
Shipping Condition: Room temperature in continental US; may vary elsewhere.
Storage Condition: Powder -20°C for 3 years, 4°C for 1 year;
Shelf Life: ≥36 months if stored properly.
Stock Solution Storage: DMSO: 4oC for 3 months.
Drug Formulation: To be determined.
HS Tariff Code: 2934.99.9001
How to use
D-1MT was used at 10-50 µM final concentration in various in vitro assays.
D-1MT was dosed at 5 mg/Kg orally to mice bearing A20 B-cell lymphoma.
- Rytelewski M, et al. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. (2014) PLoS One. 9(2):e90439.
- Nakamura N, et al. Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. (2015) Int J Hematol. 102(3):327-34.
Products are for research use only. Not for human use.
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