ORY-1001 (RG-6016), LSD1 Inhibitor


Catalog No. size PriceQuantity
M60295-2S 2 mg solid $129
M60295-10S 10mg solid $529

Description

ORY-1001 is a highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) with IC50 <20 nM. It is highly selective over related enzymes such as MAO-A/B. ORY-1001 affects AML stem cells, a sub-population of cancer cells that has been proposed to be responsible for frequent relapses of the disease. It significantly reduces tumor cell load and increases survival time in mouse models of Acute Lymphoblastic Leukaemia. Currently ORY-1001 is in Phase I/IIA clinical trial for acute leukemia.

Product information

CAS Number: 1431326-61-2

Molecular Weight: 303.27

Formula: C15H24Cl2N2

Synonym:

RG-6016

Chemical Name: N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine hydrochloride

Smiles: Cl.Cl.NC1CCC(CC1)N[C@@H]1C[C@H]1C1C=CC=CC=1

InChiKey: UCINOBZMLCREGM-RNNUGBGQSA-N

InChi: InChI=1S/C15H22N2.2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11;;/h1-5,12-15,17H,6-10,16H2;2*1H/t12?,13?,14-,15+;;/m0../s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 15 mM; Water up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

ORY-1001 was used at 1 µM in vitro.

Products are for research use only. Not for human use.

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