SW033291, 15-PGDH Inhibitor

Catalog No. size PriceQuantity
M60298-2S 2 mg solid $99
M60298-10S 10 mg solid $401


SW033291 is a highly potent and selective inhibitor of 15-PGDH enzyme with IC50 1.5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15-PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3.5-fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. SW033291is a good compound to validate 15-PGDH inhibition could be a new therapeutic strategy for tissue regeneration in diverse clinical contexts.

Product information

CAS Number: 459147-39-8

Molecular Weight: 412.59

Formula: C21H20N2OS3

Chemical Name: 2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine

Smiles: CCCCS(=O)C1SC2=NC(=CC(=C2C=1N)C1C=CC=CC=1)C1=CC=CS1


InChi: InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

SW033291 was used at 1 µM in vitro and cellular assays.

In Vivo:

SW033291 was dosed to mice by intraperitoneal injection at 5-10 mg/Kg once or twice per day.


  1. Zhang Y, et al. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. (2015) Science. 348(6240):aaa2340.

Products are for research use only. Not for human use.


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