SW033291 is a highly potent and selective inhibitor of 15-PGDH enzyme with IC50 1.5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15-PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3.5-fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. SW033291is a good compound to validate 15-PGDH inhibition could be a new therapeutic strategy for tissue regeneration in diverse clinical contexts.
CAS Number: 459147-39-8
Molecular Weight: 412.59
Chemical Name: 2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 50 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
SW033291 was used at 1 µM in vitro and cellular assays.
SW033291 was dosed to mice by intraperitoneal injection at 5-10 mg/Kg once or twice per day.
- Zhang Y, et al. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. (2015) Science. 348(6240):aaa2340.
Products are for research use only. Not for human use.
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