Napabucasin (BBI608), STAT3 Inhibitor


Catalog No. size PriceQuantity
M60303-2S 2 mg solid $89
M60303-10S 10mg solid $365
M60303-100S 100mg solid $1,620

Description

Napabucasin (BBI608) is a potent and selective STAT3 inhibitor. Napabucasin can inhibit gene transcription driven by Stat3 and cancer stemness properties, can inhibit stemness gene expression and block spherogenesis of or kill stemness-high cancer cells isolated from a variety of cancer types (IC50 ~0.14-1.25 µM), but not hematopoietic stem cells. Napabucasin inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice.

Product information

CAS Number: 83280-65-3

Molecular Weight: 240.21

Formula: C14H8O4

Synonym:

BBI608

BBI 608

BB-I608

Napabucasin

Chemical Name: 2-acetylnaphtho[2,3-b]furan-4,9-dione

Smiles: CC(=O)C1=CC2=C(O1)C(=O)C1=CC=CC=C1C2=O

InChiKey: DPHUWDIXHNQOSY-UHFFFAOYSA-N

InChi: InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 20 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Napabucasin (BBI608) was used at 0.5-2 µM final concentration in various assays.

In Vivo:

Napabucasin (BBI608) can be dosed to mice at 50 mg/Kg by IP injection once per day in xenograft models.

References:

  1. Li Y, et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. (2015)Proc Natl Acad Sci USA. 112(6):1839-44.

Products are for research use only. Not for human use.

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