BAY11-7082, E2 Ubiquitin Conjugating Enzyme Inhibitor

Catalog No. size PriceQuantity
M60309-2S 2 mg solid $89
M60309-10S 10mg solid $352


BAY11-7082 is a potent and selective E2 ubiquitin (Ub) conjugating enzyme inhibitor. It inhibits the conjugation of Ub to a range of E2 enzymes and inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. BAY11-7082 also reversibly activates MAPK signaling and induces apoptosis of leukemic T cell and B-cell lymphoma cell lines.

Product information

CAS Number: 19542-67-7

Molecular Weight: 207.25

Formula: C10H9NO2S

Chemical Name: (E)-3-tosylacrylonitrile

Smiles: CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N


InChi: InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

BAY11-7082 was used at 10-20 µM final concentration in various assays.


  1. Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. (1997) J Biol Chem. 272(34):21096-103.
  2. Mori N, et al. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. (2002) Blood. 100(5):1828-34.
  3. Strickson S, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. (2013) Biochem J. 451(3):427-37.

Products are for research use only. Not for human use.


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