PD-1/PD-L1 Inhibitor C1

Catalog No. size PriceQuantity
M60312-2S 2 mg solid $109
M60312-10S 10 mg solid $431


Product Information
Molecular Weight: 475.58
Formula: C29H33NO5
Purity: ≥98%
CAS#: 1675201-83-8
Solubility: DMSO up to 100 mM; Water up to 100 mM
Chemical Name: (S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

PD-1/PD-L1 inhibitor C1 is a potent and selective small molecule inhibitor of the PD-1/PD-L1 protein/protein interactions with IC50 < 100 nM (PD-1/PD-L1 Homogenous Time-Resolved Fluorescence (HTRF) binding assay). It may potentially be useful in the treatment of cancer as well as infectious diseases such as hepatitis C. The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis.

How to Use:

In vitro: PD-1/PD-L1 Inhibitor C1 was used at 10 µM final concentration in various assays.
In vivo: n/a


  1. Chupak, L.S. and Zheng, X. Compounds useful as immunomodulators. WO 2015/034820 (2015). 


Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed