|Solubility:||DMSO up to 100 mM; Water up to 100 mM|
|Chemical Name:||(S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
PD-1/PD-L1 inhibitor C1 is a potent and selective small molecule inhibitor of the PD-1/PD-L1 protein/protein interactions with IC50 < 100 nM (PD-1/PD-L1 Homogenous Time-Resolved Fluorescence (HTRF) binding assay). It may potentially be useful in the treatment of cancer as well as infectious diseases such as hepatitis C. The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis.
How to Use:
In vitro: PD-1/PD-L1 Inhibitor C1 was used at 10 µM final concentration in various assays.
In vivo: n/a
- Chupak, L.S. and Zheng, X. Compounds useful as immunomodulators. WO 2015/034820 (2015).
Products are for research use only. Not for human use.
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