MSAB is a potent and selective Wnt/β-catenin inhibitor identified using cell-based chemical screening. It binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects selectively on Wnt-dependent cancer cells in vitro and in mouse cancer models.
CAS Number: 173436-66-3
Molecular Weight: 305.35
Chemical Name: methyl 3-((4-methylphenyl)sulfonamido)benzoate
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
MSAB was suggested to be used at 5-10 µM final concentration in vitro.
MSAB was used to dose mice at 10-20 mg/kg by intraperitoneal injection once per day in xenograft model of HCT116, HCT115 and H23 cell lines, and MMTV-Wnt1 transgenic mice.
- 1. Hwang SY, et al. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. (2016) Cell Rep. 16(1):28-36.
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