MSAB, β-catenin Inhibitor

Catalog No. size PriceQuantity
M60316-2 2mg solid $80
M60316-10 10mg solid $240


MSAB is a potent and selective Wnt/β-catenin inhibitor identified using cell-based chemical screening. It binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects selectively on Wnt-dependent cancer cells in vitro and in mouse cancer models.

Product information

CAS Number: 173436-66-3

Molecular Weight: 305.35

Formula: C15H15NO4S

Chemical Name: methyl 3-((4-methylphenyl)sulfonamido)benzoate

Smiles: CC1C=CC(=CC=1)S(=O)(=O)NC1=CC(=CC=C1)C(=O)OC


InChi: InChI=1S/C15H15NO4S/c1-11-6-8-14(9-7-11)21(18,19)16-13-5-3-4-12(10-13)15(17)20-2/h3-10,16H,1-2H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

MSAB was suggested to be used at 5-10 µM final concentration in vitro.

In Vivo:

MSAB was used to dose mice at 10-20 mg/kg by intraperitoneal injection once per day in xenograft model of HCT116, HCT115 and H23 cell lines, and MMTV-Wnt1 transgenic mice.


  1. 1. Hwang SY, et al. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. (2016) Cell Rep. 16(1):28-36.

Products are for research use only. Not for human use.


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