|Solubility:||DMSO up to 100 mM; Water up to 100 mM|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
BI-7273 is a potent, selective and cell-permeable BRD9 inhibitor with IC50 ~19 nM (Alpha assay). It also inhibits BRD7 with IC50 ~117 nM (Alpha assay). It has high selectivity against the other bromodomain family members (48 bromodomains) and kinases. In EOL-1 cellular proliferation assay, BI-7273 has IC50 at 1400 nM. It has very good pharmacokinetic profiling. BI-7273 together with BI-9546, could be useful chemical tools to further explore BRD9 bromodomain biology in both in vitro and in vivo settings.
How to Use:
In vitro: BI-7273 was used at 1-10 µM in vitro and cellular assays.
In vivo: BI-7273 was orally dosed to mice at 180 mg/kg once per day.
- Martin LJ, et al. Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. (2016) J Med Chem. 59(10):4462-75.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.