GN44028, HIF-1α Inhibitor


Catalog No. size PriceQuantity
M60325-2S 2 mg solid $89
M60325-10S 10 mg solid $360

Description

Product Information
Molecular Weight: 305.33
Formula: C18H15N3O2
Purity: ≥98%
CAS#: 1421448-26-1
Solubility: DMSO up to 100 mM; EtOH up to 100 mM
Chemical Name: N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

GN44028 is potent and selective HIF-1α inhibitor with IC50 ~14 nM. It inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization in nuclei under the hypoxic conditions. This suggests that GN44028 probably affected the transcriptional pathway induced by the HIF-1α/HIF-1β heterodimer.

How to Use:

In vitro: GN44028 was used at 1-10 µM in vitro and cellular assays.
In vivo: n/a

Reference:

  • 1. Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. (2013) ACS Med Chem Lett. 4(2):297-301.   
Products are for research use only. Not for human use.

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