GN44028, HIF-1α Inhibitor


Catalog No. size PriceQuantity
M60325-2S 2 mg solid $89
M60325-10S 10 mg solid $360

Description

GN44028 is potent and selective HIF-1α inhibitor with IC50 ~14 nM. It inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization in nuclei under the hypoxic conditions. This suggests that GN44028 probably affected the transcriptional pathway induced by the HIF-1α/HIF-1β heterodimer.

Product information

CAS Number: 1421448-26-1

Molecular Weight: 305.33

Formula: C18H15N3O2

Chemical Name: N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Smiles: C1C2C(NC3=CC4OCCOC=4C=C3)=NNC=2C2=CC=CC=C21

InChiKey: CGZKSZVSWAAUHE-UHFFFAOYSA-N

InChi: InChI=1S/C18H15N3O2/c1-2-4-13-11(3-1)9-14-17(13)20-21-18(14)19-12-5-6-15-16(10-12)23-8-7-22-15/h1-6,10H,7-9H2,(H2,19,20,21)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM; EtOH up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

GN44028 was used at 1-10 µM in vitro and cellular assays.

References:

  1. Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. (2013) ACS Med Chem Lett. 4(2):297-301.

Products are for research use only. Not for human use.

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