CPI-455, KDM5 Demethylases Inhibitor


Catalog No. size PriceQuantity
M60326-2S 2 mg solid $129
M60326-10S 10mg solid $522

Description

CPI-455 is a potent and selective inhibitor of KDM5 demethylases which reduces survival of drug-tolerant cancer cells. CPI-455 mediated KDM5 inhibition, elevated global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents. Pretreatment of cancer cells with a KDM5-specific inhibitor results in the ablation of a subpopulation of cancer cells that can serve as the founders for therapeutic relapse.

Product information

CAS Number: 1628208-23-0

Molecular Weight: 278.31

Formula: C16H14N4O

Chemical Name: 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

Smiles: CC(C)C1C(=O)N2N=CC(C#N)=C2NC=1C1C=CC=CC=1

InChiKey: DHXKRMSKXLDZGY-UHFFFAOYSA-N

InChi: InChI=1S/C16H14N4O/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21/h3-7,9-10,19H,1-2H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

KDM5-C70 was used at 1-10 µM in vitro and cellular assays.

References:

  1. Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. (2016) Nat Chem Biol. 12(7):531-8.

Products are for research use only. Not for human use.

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