ME0328, PARP-3 Inhibitor

Catalog No. size PriceQuantity
M60329-2S 2 mg solid $109
M60329-10S 10mg solid $431


Product Information
Molecular Weight: 321.37
Formula: C19H19N3O2
Purity: ≥98%
CAS#: 1445251-22-8
Solubility: DMSO up to 100 mM
Chemical Name: (S)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

ME0328 is a potent, selective and cell permeable PARP-3 inhibitor with IC50 of 0.89 μM. It has good selectivity against PARP-1, PARP-2 and other ARDT enzymes. Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells.

How to Use:

In vitro: ME0328 was used at 10 µM in vitro and cellular assays.
In vivo: n/a


  • 1. Lindgren AE, et al. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. (2013) ACS Chem Biol. 8(8):1698-703. 
  • 2. Wang H, et al. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. (2017) Cancer Lett. 385:137-143. 
  • 3. Day TA, et al. PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. (2017) Nat Commun. 8:15110. 


Products are for research use only. Not for human use. 

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