ME0328 is a potent, selective and cell permeable PARP-3 inhibitor with IC50 of 0.89 μM. It has good selectivity against PARP-1, PARP-2 and other ARDT enzymes. Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells.
CAS Number: 1445251-22-8
Molecular Weight: 321.37
Chemical Name: (S)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
ME0328 was used at 10 µM in vitro and cellular assays.
- Lindgren AE, et al. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. (2013) ACS Chem Biol. 8(8):1698-703.
- Wang H, et al. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. (2017) Cancer Lett. 385:137-143.
- Day TA, et al. PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. (2017) Nat Commun. 8:15110.
Products are for research use only. Not for human use.
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