Catalog No. size PriceQuantity
M6414-2 2mg solid $93
M6414-10 10mg solid $365



Product Information

(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.


IC50 & Target: BET bromodomain


Molecular Weight: 456.99


Formula: C₂₃H₂₅ClN₄O₂S


Smiles Code:




Room temperature in continental US; may vary elsewhere.



Powder    -20°C  3 years

4°C  2 years

In solvent -80°C  6 months

-20°C  1 month


In Vitro:

  • -(-)-JQ1 Enantiomer shows no significant interaction with any bromodomain. Besides, (R)-(-)-JQ1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC).





  1. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.


  1. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.


Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed