(-)-JQ-1


Catalog No. size PriceQuantity
M6414-2 2mg solid $93
M6414-10 10mg solid $365

Description

Cas:1268524-71-5

Product Information

(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.

 

IC50 & Target: BET bromodomain

 

Molecular Weight: 456.99

 

Formula: C₂₃H₂₅ClN₄O₂S

 

Smiles Code:

O=C(C[C@H]1N=C(C2=C(N3C1=NN=C3C)SC(C)=C2C)C4=CC=C(C=C4)Cl)OC(C)(C)C

 

Shipping:

Room temperature in continental US; may vary elsewhere.

 

Storage:

Powder    -20°C  3 years

4°C  2 years

In solvent -80°C  6 months

-20°C  1 month

 

In Vitro:

  • -(-)-JQ1 Enantiomer shows no significant interaction with any bromodomain. Besides, (R)-(-)-JQ1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC).

 

 

References

 

  1. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.

 

  1. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.

 

Products are for research use only. Not for human use.

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