（-）-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (-)-JQ-1 Enantiomer has no effect.
CAS Number: 1268524-71-5
Molecular Weight: 456.99
Chemical Name: 6H-Thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2, 3, 9-trimethyl-, 1, 1-dimethylethyl ester, (6R)-
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: ≥ 22.8mg/mL in DMSO, ≥ 46.9 mg/mL in EtOH with ultrasonic
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
(-)-JQ-1 Enantiomer shows no significant interaction with any bromodomain. Besides, (-)-JQ-1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC).
- Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
- Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.
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