Description
LHW090-A7 is a compound developed as an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins.1 Inhibitors of NEP have been shown to increase plasma levels of endogenous atrial natriuretic peptides and, as such, are expected to induce natriuretic and diuretic effects.
Product information
CAS Number: 1308256-94-1
Molecular Weight: 375.85
Formula: C20H22ClNO4
Synonym:
LHW090 A7
LHW090 Analog 7
LHW090A7
LHW090-A7
Chemical Name: (2S)-3-[4-(3-Chlorophenyl)phenyl]-2-[[(2S)-1-ethoxy-1-oxopropan-2-yl]amino]propanoic acid
Smiles: C[C@H](N[C@@H](CC1C=CC(=CC=1)C1=CC(Cl)=CC=C1)C(O)=O)C(=O)OCC
InChiKey: PWYAUIUPDMSWJH-UGSOOPFHSA-N
InChi: InChI=1S/C20H22ClNO4/c1-3-26-20(25)13(2)22-18(19(23)24)11-14-7-9-15(10-8-14)16-5-4-6-17(21)12-16/h4-10,12-13,18,22H,3,11H2,1-2H3,(H,23,24)/t13-,18-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Iwaki, Y. ,Kawanami, T. ,Ksander, G. M., et al. Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors. (2011).
Products are for research use only. Not for human use.
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