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M6430-2 2mg solid $116
M6430-10 10mg solid $476


CFTRinh172 is a voltage-independent, selective CFTR chloride channel blocker that alters channel gating.

Product information

CAS Number: 307510-92-5

Molecular Weight: 409.40

Formula: C18H10F3NO3S2


CFTR Inhibitor-172

CFTR Inhibitor 172

CFTR Inhibitor172


CFTR(Inh) 172


CFTR Inh-172

CFTR Inh 172

CFTR Inh172

Chemical Name: 4-{[(5Z)-4-Oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl}benzoic acid

Smiles: OC(=O)C1C=CC(/C=C2\SC(=S)N(C3=CC(=CC=C3)C(F)(F)F)C\2=O)=CC=1


InChi: InChI=1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Inhibition by CFTRinh172 is complete in approximately 10 minutes (t1/2=4 minutes) and is reversed after ishout with t1/2 approximately 5 minutes. CFTRinh172 is nontoxic to FRT cells after 24 hours at concentrations up to 100 μM. CFTRinh172 does not alter CFTR unitary conductance (8 pS), but reduces open probability by > 90% with Ki=0.6 μM. This effect is due to increased mean channel closed time without changing mean channel open time. The Ki values for inhibition of Cl-current in wild-type, G551D, and G1349D CFTR are about 0.5 μM; however, Ki is significantly reduced to 0.2 μM for vF508 CFTR.

In Vivo:

A single intraperitoneal injection of CFTRinh172 (250 μg/kg) in mice reduces by more than 90% cholera toxin–induced fluid secretion in the small intestine over 6 hours. CFTRinh172 is nontoxic at high concentrations in mouse models. CFTRinh172 significantly reduces fluid secretion to that in saline control loops, whereas an inactive CFTRinh172 analog does not inhibit fluid secretion.


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Products are for research use only. Not for human use.

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