Alda-1


Catalog No. size PriceQuantity
M6452-2 2mg solid $77
M6452-10 10mg solid $328

Description

Cas:349438-38-6

Product Information

Alda-1 is a potent and selective Aldehyde Dehydrogenase-2 Agonist. Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes. Pharmacological activation of ALDH2 by Alda-1 reversed alcoholic steatosis and apoptosis through accelerating aldehyde clearance. This study indicates that ALDH2 is a promising molecular target and Alda-1 has therapeutic potential for treating alcoholic liver disease.

 

Chemical Formula: C15H11Cl2NO3

 

Exact Mass: 323.0116

 

Molecular Weight: 324.16

 

Elemental Analysis: C, 55.58; H, 3.42; Cl, 21.87; N, 4.32; O, 14.81

 

Synonym: 

 

Alda-1

Alda1

Alda 1

 

Chemical Name:  

N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

 

InChi Key:

NMKJFZCBCIUYHI-UHFFFAOYSA-N

 

InChi Code:   InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)

 

Smiles Code:

O=C(NCC1=CC=C(OCO2)C2=C1)C3=C(Cl)C=CC=C3Cl

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vivo

Alda-1 treatment results in a significant decrease of 4-HNE-protein content in the plasma of apoE−/− mice. Alda-1 administration leads to a slight increase in gene expression related to neurogenesis (Nog), mitochondrial biogenesis (CYTB, ND1), and apoptosis (Bax, Gsk3b) in the Hp of apoE−/− mice. Alda-1 administration leads to 2 and 10 differentially expressed proteins in the FCx and Hp of apoE−/− mice, respectively. Alda-1 (1.5 mg/kg, b.w., i.p.) administration significantly increases the climbing time, tends to reduce the immobility time and increases the swimming time of the prenatally stressed rats in the forced swim test. Moreover, treatment of prenatally stressed rats with Alda-1 significantly increases number of entries into the open arms of the maze and the time spent therein, as assessed by elevated plus-maze test. Alda-1 (8.5 mg/kg, i.p.) with glucose significantly lowers 4-HNE and FJB-positive cells in the cerebral cortex of Alda-1-treated rats than in DMSO-treated rats 24 h after glucose administration. Alda-1 (10 mg/kg per day) treatment prevents aldehydic overload, mitochondrial dysfunction and improves ventricular function in post-MI cardiomyopathy rats.

 

 

References

 

  1. Stachowicz A, Głombik K, Olszanecki R, Basta-Kaim A, Suski M, Lasoń W, Korbut R. The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression. Brain Behav Immun. 2015 Aug 4. pii: S0889-1591(15)00428-6. doi: 10.1016/j.bbi.2015.08.004. [Epub ahead of print] PubMed PMID: 26254233.

 

  1. Ikeda T, Takahashi T, Tsujita M, Kanazawa M, Toriyabe M, Koyama M, Itoh K, Nakada T, Nishizawa M, Shimohata T. Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. PLoS One. 2015 Jun 17;10(6):e0128844. doi: 10.1371/journal.pone.0128844. eCollection 2015. PubMed PMID: 26083658; PubMed Central PMCID: PMC4471358.

 

  1. Zhong W, Zhang W, Li Q, Xie G, Sun Q, Sun X, Tan X, Sun X, Jia W, Zhou Z. Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. J Hepatol. 2015 Jun;62(6):1375-81. doi: 10.1016/j.jhep.2014.12.022. Epub 2014 Dec 24. PubMed PMID: 25543082.

 

  1. Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. Int J Cardiol. 2015 Jan 20;179:129-38. doi: 10.1016/j.ijcard.2014.10.140. Epub 2014 Oct 23. PubMed PMID: 25464432; PubMed Central PMCID: PMC4405147.

 

  1. Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat Struct Mol Biol. 2010 Feb;17(2):159-64. doi: 10.1038/nsmb.1737. Epub 2010 Jan 10. PubMed PMID: 20062057; PubMed Central PMCID: PMC2857674.

 

Products are for research use only. Not for human use.

 

 

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