DiMC is a more metabolically stable analog of curcumin, inducing epigenetic changes in leukemia cells and the expression of promoter methylated genes.
Chemical Formula: C23H24O6
Exact Mass: 396.1573
Molecular Weight: 396.439
Elemental Analysis: C, 69.68; H, 6.10; O, 24.21
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Zhao H, Liu Q, Wang S, Dai F, Cheng X, Cheng X, Chen W, Zhang M, Chen D. In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. Cancer Med. 2017 Jul;6(7):1698-1706. doi: 10.1002/cam4.1114. Epub 2017 Jun 2. PubMed PMID: 28573788; PubMed Central PMCID: PMC5504307.
Teymouri M, Barati N, Pirro M, Sahebkar A. Biological and pharmacological evaluation of dimethoxycurcumin: A metabolically stable curcumin analogue with a promising therapeutic potential. J Cell Physiol. 2018 Jan;233(1):124-140. doi: 10.1002/jcp.25749. Epub 2017 Mar 31. Review. PubMed PMID: 27996095.
Chen D, Dai F, Chen Z, Wang S, Cheng X, Sheng Q, Lin J, Chen W. Dimethoxy Curcumin Induces Apoptosis by Suppressing Survivin and Inhibits Invasion by Enhancing E-Cadherin in Colon Cancer Cells. Med Sci Monit. 2016 Sep 11;22:3215-22. PubMed PMID: 27614381; PubMed Central PMCID: PMC5021015.
Hassan HE, Keita JA, Narayan L, Brady SM, Frederick R, Carlson S, Glass KC, Natesan S, Buttolph T, Fandy TE. The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect. Epigenetics. 2016 Sep 2:1-10. [Epub ahead of print] PubMed PMID: 27588609; PubMed Central PMCID: PMC5094623.
Adeyeni TA, Khatwani N, San K, Ezekiel UR. BMI1 is downregulated by the natural compound curcumin, but not by bisdemethoxycurcumin and dimethoxycurcumin. Physiol Rep. 2016 Aug;4(16). pii: e12906. doi: 10.14814/phy2.12906. PubMed PMID: 27550987; PubMed Central PMCID: PMC5002914.
Products are for research use only. Not for human use.
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