ETH 2120

ETH 2120, also known as Sodium ionophore III, is a ionophore. Ionophore is suitable for the assay of sodium activity in blood, plasma, serum. etc. with a solvent polymeric membrane electrode.

Product information

CAS Number: 81686-22-8

Molecular Weight: 552.79

Formula: C34H52N2O4

Synonym:

ETH-2120

Sodium ionophore III

ETH 2120

ETH2120

Chemical Name: N,N,N′,N′-Tetracyclohexyl-1,2-phenylenedioxydiacetamide

Smiles: O=C(COC1=CC=CC=C1OCC(=O)N(C1CCCCC1)C1CCCCC1)N(C1CCCCC1)C1CCCCC1

InChiKey: GKRBLFCTFPAHMH-UHFFFAOYSA-N

InChi: InChI=1S/C34H52N2O4/c37-33(35(27-15-5-1-6-16-27)28-17-7-2-8-18-28)25-39-31-23-13-14-24-32(31)40-26-34(38)36(29-19-9-3-10-20-29)30-21-11-4-12-22-30/h13-14,23-24,27-30H,1-12,15-22,25-26H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Preincubation of the cells with the Na+ ionophore ETH 2120 not only stimulated caffeate reduction, but completely abolished ATP synthesis. Addition of ETH 2120 to cells in the steady state of caffeate reduction immediately dissipated the intracellular ATP level. Lactate-sulfate grown cells are insensitive to the Na+ ionophore, ETH 2120. ETH 2120 ligand is a very effective receptor for the Eu3+ and Am3+ cations and can be considered as a potential extraction agent for nuclear iste treatment.

References:

1. Imkamp F, et al. Chemiosmotic energy conservation with Na(+) as the coupling ion during hydrogen-dependent caffeate reduction by Acetobacterium woodii. J Bacteriol. 2002 Apr;184(7):1947-51.
2. Wang L, et al. The role of Rnf in ion gradient formation in Desulfovibrio alaskensis. PeerJ. 2016 Apr 14;4:e1919.
3. Makrlík, E, et al. Sodium Ionophore III as Very Effective Receptor for Trivalent Europium and Americium.J Solution Chem (2016) 45: 463.

Products are for research use only. Not for human use.