TUG-891


Catalog No. size PriceQuantity
M6522-2 2mg solid $84
M6522-10 10mg solid $312

Description

Cas:1374516-07-0

Product Information:

TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG-891 also resulted in rapid phosphorylation and internalization of the receptor. TUG-891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo in this species.

 

Chemical Formula: C23H21FO3

 

Exact Mass: 364.1475

 

Molecular Weight: 364.4164

 

Elemental Analysis: C, 75.81; H, 5.81; F, 5.21; O, 13.17

 

Synonym: 

 

TUG-891

TUG 891

TUG891

 

Chemical Name:

3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

 

InChi Key: 

LPGBXHWIQNZEJB-UHFFFAOYSA-N

 

InChi Code:

InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26)

 

Smiles Code:

CC1=CC=C(C2=CC=C(F)C=C2COC3=CC=C(CCC(O)=O)C=C3)C=C1

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor.

 

 

References

 

  1. Hopkins MM, Zhang Z, Liu Z, Meier KE. Eicosopentaneoic Acid and Other Free Fatty Acid Receptor Agonists Inhibit Lysophosphatidic Acid- and Epidermal Growth Factor-Induced Proliferation of Human Breast Cancer Cells. J Clin Med. 2016 Jan 26;5(2). pii: E16. doi: 10.3390/jcm5020016. PubMed PMID: 26821052; PubMed Central PMCID: PMC4773772.

 

  1. Anbazhagan AN, Priyamvada S, Gujral T, Bhattacharyya S, Alrefai WA, Dudeja PK, Borthakur A. A Novel Anti-inflammatory Role of GPR120 in Intestinal Epithelial Cells. Am J Physiol Cell Physiol. 2016 Jan 20:ajpcell.00123.2015. doi: 10.1152/ajpcell.00123.2015. [Epub ahead of print] PubMed PMID: 26791484.

 

  1. Gao B, Huang Q, Jie Q, Lu WG, Wang L, Li XJ, Sun Z, Hu YQ, Chen L, Liu BH, Liu J, Yang L, Luo ZJ. GPR120: A bi-potential mediator to modulate the osteogenic and adipogenic differentiation of BMMSCs. Sci Rep. 2015 Sep 14;5:14080. doi: 10.1038/srep14080. PubMed PMID: 26365922; PubMed Central PMCID: PMC4568495.

 

  1. Mizuta K, Zhang Y, Mizuta F, Hoshijima H, Shiga T, Masaki E, Emala CW Sr. Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L970-82. doi: 10.1152/ajplung.00041.2015. Epub 2015 Sep 4. PubMed PMID: 26342087; PubMed Central PMCID: PMC4628981.

 

  1. Song T, Peng J, Ren J, Wei HK, Peng J. Cloning and characterization of spliced variants of the porcine G protein coupled receptor 120. Biomed Res Int. 2015;2015:813816. doi: 10.1155/2015/813816. Epub 2015 May 17. PubMed PMID: 26075265; PubMed Central PMCID: PMC4449883.

 

Products are for research use only. Not for human use.

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