DB07268

Cas：929007-72-7

Product Information：

DB07268 is is a potent and selective JNK1 inhibitor.

Chemical Formula: C17H15N5O2

Exact Mass: 321.1226

Molecular Weight: 321.34

Elemental Analysis: C, 63.54; H, 4.71; N, 21.79; O, 9.96

Synonym:

DB07268

DB-07268

DB 07268

Chemical Name: 

2-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)amino)benzamide

InChi Key:

QHPKKGUGRGRSGA-UHFFFAOYSA-N

InChi Code: 

InChI=1S/C17H15N5O2/c18-16(24)13-6-1-2-7-14(13)21-15-8-9-19-17(22-15)20-11-4-3-5-12(23)10-11/h1-10,23H,(H2,18,24)(H2,19,20,21,22)

Smiles Code:

O=C(C1=CC=CC=C1NC2=NC(NC3=CC=CC(O)=C3)=NC=C2)N

Technical Data：

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

In Vitro:

DB07268 (Compound 2b) also inhibits CHK1, PAK4, AKT1, and ERK2 with IC50s of 0.82 μM, 5.5 μM, 15 μM, and 25 μM, respectively.

References：

1. Liu M, et al. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72.

Products are for research use only. Not for human use.