DB07268


Catalog No. size PriceQuantity
M6530-2 2mg solid $124
M6530-10 10mg solid $488

Description

Cas:929007-72-7

Product Information:

DB07268 is is a potent and selective JNK1 inhibitor.

 

Chemical Formula: C17H15N5O2

 

Exact Mass: 321.1226

 

Molecular Weight: 321.34

 

Elemental Analysis: C, 63.54; H, 4.71; N, 21.79; O, 9.96

 

Synonym:

 

DB07268

DB-07268

DB 07268

 

Chemical Name: 

2-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)amino)benzamide

 

InChi Key:

QHPKKGUGRGRSGA-UHFFFAOYSA-N

 

InChi Code: 

InChI=1S/C17H15N5O2/c18-16(24)13-6-1-2-7-14(13)21-15-8-9-19-17(22-15)20-11-4-3-5-12(23)10-11/h1-10,23H,(H2,18,24)(H2,19,20,21,22)

 

Smiles Code:

O=C(C1=CC=CC=C1NC2=NC(NC3=CC=CC(O)=C3)=NC=C2)N

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

DB07268 (Compound 2b) also inhibits CHK1, PAK4, AKT1, and ERK2 with IC50s of 0.82 μM, 5.5 μM, 15 μM, and 25 μM, respectively.

 

 

References:

 

  1. Liu M, et al. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72.

 

Products are for research use only. Not for human use.

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