ML-329


Catalog No. size PriceQuantity
M6543-2 2mg solid $130
M6543-10 10mg solid $510

Description

ML-329 is an inhibitor of the microphthalmia-associated transcription factor (MITF) pathway with an IC50 value of 1.2 μM for promoter activity of the MITF target gene TRPM-1. ML-329 showed specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML-329 reduced the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML-329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.

Product information

CAS Number: 19992-50-8

Molecular Weight: 328.34

Formula: C16H12N2O4S

Synonym:

CID-12387471

CID 12387471

CID12387471

ML 329

ML329

Chemical Name: 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide

Smiles: NS(=O)(=O)C1C=CC(=CC=1)NC1=CC(=O)C2=CC=CC=C2C1=O

InChiKey: CSYFFQVEQXEIAB-UHFFFAOYSA-N

InChi: InChI=1S/C16H12N2O4S/c17-23(21,22)11-7-5-10(6-8-11)18-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9,18H,(H2,17,21,22)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 5 mg/mL (15.23 mM; Need ultrasonic) DMF : 5 mg/mL (15.23 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

ML-329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML-329 could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with ML-329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. ML-329 shows specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML-329 reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML-329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.

References:

  1. Faloon PW, Bennion M, Weiner WS, et al. A Small Molecule Inhibitor of the MITF Molecular Pathway. In: Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010.

Products are for research use only. Not for human use.

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