Catalog No. size PriceQuantity
M6551-2 2mg solid $121
M6551-10 10mg solid $482



Product Information:

CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. CYM-5442 significantly inhibited but did not prevent aGVHD. CYM-5442 treatment downregulated CCL2 and CCL7 expression in endothelial cells, therefore reducing the migration of monocytes, from which tissue macrophages originate. CYM-5442 may be a potential therapeutic regimen for aGVHD.


Chemical Formula: C23H27N3O4


Exact Mass: 409.2002


Molecular Weight: 409.486


Elemental Analysis: C, 67.46; H, 6.65; N, 10.26; O, 15.63





CYM 5442



Chemical Name: 2-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)amino)ethan-1-ol


InChi Key:



InChi Code: InChI=1S/C23H27N3O4/c1-3-28-20-11-8-15(14-21(20)29-4-2)23-25-22(26-30-23)18-7-5-6-17-16(18)9-10-19(17)24-12-13-27/h5-8,11,14,19,24,27H,3-4,9-10,12-13H2,1-2H3


Smiles Code:




Technical Data:

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001





  1. Li C, Li JN, Kays J, Guerrero M, Nicol GD. Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation. 2015 Apr 12;12:70. doi: 10.1186/s12974-015-0286-8. PubMed PMID: 25880547; PubMed Central PMCID: PMC4397880.


  1. Cheng Q, Ma S, Lin D, Mei Y, Gong H, Lei L, Chen Y, Zhao Y, Hu B, Wu Y, Yu X, Zhao L, Liu H. The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. Cell Mol Immunol. 2015 Nov;12(6):681-91. doi: 10.1038/cmi.2014.59. Epub 2014 Aug 4. PubMed PMID: 25088224.


  1. Costes LM, van der Vliet J, Farro G, Matteoli G, van Bree SH, Olivier BJ, Nolte MA, Boeckxstaens GE, Cailotto C. The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus. PLoS One. 2014 Jul 10;9(7):e102211. doi: 10.1371/journal.pone.0102211. eCollection 2014. PubMed PMID: 25010202; PubMed Central PMCID: PMC4092106.


  1. Janes K, Little JW, Li C, Bryant L, Chen C, Chen Z, Kamocki K, Doyle T, Snider A, Esposito E, Cuzzocrea S, Bieberich E, Obeid L, Petrache I, Nicol G, Neumann WL, Salvemini D. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem. 2014 Jul 25;289(30):21082-97. PubMed PMID: 24876379; PubMed Central PMCID: PMC4110312.


  1. Parrill AL, Lima S, Spiegel S. Structure of the first sphingosine 1-phosphate receptor. Sci Signal. 2012 May 22;5(225):pe23. doi: 10.1126/scisignal.2003160. PubMed PMID: 22623751; PubMed Central PMCID: PMC3632326.


Products are for research use only. Not for human use.


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