DMAT


Catalog No. size PriceQuantity
M6562-2 2mg solid $100
M6562-10 10mg solid $411

Description

Cas:749234-11-5

Product Information:

DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.

 

Molecular Weight476.79

 

FormulaC₉H₇Br₄N₃

 

Smiles Code:

CN(C)C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1

 

Shipping:

Room temperature in continental US; may vary elsewhere.

 

Storage:

Powder    -20°C   3 years

4°C   2 years

In solvent -80°C   6 months

-20°C    1 month

 

 

In Vitro:

DMAT (1 μM-2.5 μM) DMAT is more efficient in killing antiestrogen resistant cells than parental antiestrogen sensitive MCF-7 cells. DMAT-induced cell death of antiestrogen resistant cells is mediated by caspases. DMAT inhibits CK2 activity but the inhibition is similar in the three cell lines, MCF-7, TAMR-1 and 182R-6[1]. DMAT has effects on H295R cell proliferation at concentrations of 10-4 and 10-5mol/Las compared with the control. DMAT (100 μM) significantly increases apoptosis of H295R cells. DMAT (1 nM-1 μM) significantly decreases aldosterone release into supernatants of 72-h H295R cell cultures as compared with the control. DMAT also inhibits PIM1 by a mechanism which is competitive with respect to ATP, and it is a powerful inhibitor of kinases other than CK2.

 

In Vivo

DMAT application in vivo reduces tumor growth in a xenotransplant model by interference with tumor cell proliferation. Biochemical parameters and histology following DMAT administration revealed no alterations in liver tissue.

 

References

 

  1. Yde CW, et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitorDMAT. Cancer Lett. 2007 Oct 28;256(2):229-37.

 

  1. Lawnicka H, et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340(

 

  1. Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65.

 

  1. Sass G, et al. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int J Oncol. 2011 Aug;39(2):433-42.

 

Products are for research use only. Not for human use.

 

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