saclofen

Cas：125464-42-8

Product Information：

Saclofen is a selective antagonist of GABAB receptors.

Chemical Formula: C9H12ClNO3S

Exact Mass: 249.0226

Molecular Weight: 249.709

Elemental Analysis: C, 43.29; H, 4.84; Cl, 14.20; N, 5.61; O, 19.22; S, 12.84

Synonym:

Saclofen

Chemical Name:

3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid

InChi Key:

JYLNVJYYQQXNEK-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

Smiles Code:

O=S(CC(C1=CC=C(Cl)C=C1)CN)(O)=O

Technical Data：

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

References：

1. Chang CH. Lateral orbitofrontal cortical modulation on medial prefrontal cortex-amygdala pathway: Differential regulation of intra-amygdala GABAA and GABAB receptors. Int J Neuropsychopharmacol. 2017 Apr 22. doi: 10.1093/ijnp/pyx027. [Epub ahead of print] PubMed PMID: 28444246.

2. Hu C, Zhao YT, Zhang G, Xu MF. Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain. Mol Med Rep. 2017 Feb;15(2):975-980. doi: 10.3892/mmr.2016.6071. Epub 2016 Dec 23. PubMed PMID: 28035379.

3. Li G, Lv J, Wang J, Wan P, Li Y, Jiang H, Jin Q. GABAB receptors in the hippocampal dentate gyrus are involved in spatial learning and memory impairment in a rat model of vascular dementia. Brain Res Bull. 2016 Jun;124:190-7. doi: 10.1016/j.brainresbull.2016.05.006. Epub 2016 May 12. PubMed PMID: 27181927.

4. Bassi GS, do C Malvar D, Cunha TM, Cunha FQ, Kanashiro A. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. Naunyn Schmiedebergs Arch Pharmacol. 2016 Aug;389(8):851-61. doi: 10.1007/s00210-016-1248-0. Epub 2016 Apr 23. PubMed PMID: 27106212.

5. Sallam MY, El-Gowilly SM, Abdel-Galil AG, El-Mas MM. Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats. Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389(3):279-88. doi: 10.1007/s00210-015-1201-7. Epub 2015 Dec 21. PubMed PMID: 26685896.

Products are for research use only. Not for human use.