saclofen

Saclofen is a selective antagonist of GABAB receptors.

Product information

CAS Number: 125464-42-8

Molecular Weight: 249.71

Formula: C9H12ClNO3S

Chemical Name: 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid

Smiles: NCC(CS(O)(=O)=O)C1C=CC(Cl)=CC=1

InChiKey: JYLNVJYYQQXNEK-UHFFFAOYSA-N

InChi: InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Chang CH. Lateral orbitofrontal cortical modulation on medial prefrontal cortex-amygdala pathway: Differential regulation of intra-amygdala GABAA and GABAB receptors. Int J Neuropsychopharmacol. 2017 Apr 22. doi: 10.1093/ijnp/pyx027. [Epub ahead of print] PubMed PMID: 28444246.
2. Hu C, Zhao YT, Zhang G, Xu MF. Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain. Mol Med Rep. 2017 Feb;15(2):975-980. doi: 10.3892/mmr.2016.6071. Epub 2016 Dec 23. PubMed PMID: 28035379.
3. Li G, Lv J, Wang J, Wan P, Li Y, Jiang H, Jin Q. GABAB receptors in the hippocampal dentate gyrus are involved in spatial learning and memory impairment in a rat model of vascular dementia. Brain Res Bull. 2016 Jun;124:190-7. doi: 10.1016/j.brainresbull.2016.05.006. Epub 2016 May 12. PubMed PMID: 27181927.

Products are for research use only. Not for human use.